Aurogreen
Indocyanine Green for Injection

Mode Of Use

• Reconstitute with 5ml of sterile water for injection and shake well for at least 3 minutes for complete dissolution of the dye, resulting in a final concentration of 5 mg dye/ ml of water (i.e. 0.5% solution)

• The reconstituents (dye solution) should be withdrawn from the vial through the sterile syringe filter (0.2 micron) using sterile syringe and 21 gauge needle.

• The purpose of using sterile syringe filter is:

(i) To remove undissolved dye in the solution due to inadequate shaking/dissolution which cannot be observed visually since the dye solution is dark green in colour

(ii) To avoid cross-contamination at the time of reconstitution which gets into the syringe.

• Then remove the syringe filter and the 21 gauge needle from the syringe and dispose.

• Attach fresh sterile 23 gauge needle to the syringe and inject into the patient (IV)

• Use the reconstituents within ten hours

• Store below 30°C

INTERACTIONS WITH OTHER DRUGS

Concomitant use of certain drugs and injectables can alter the absorbance of ICG. Injectables containing sodium disulphite particularly in combination with heparin reduce the absorption.

The following drugs reduce the absorption rate -anticonvulsants, disulphite compounds, haloperidol, heroin, meperidine, metamizol, methadone, morphium, nitrofurantoin, opium alkaloids, phenobarbital, phenylbutazone.

Drugs like cyclopropane, probenicid and rifamycin increase the absorption.